9781118295151

Now with twenty five percent more entries, double the number of illustrations, and an updated and extensive bibliography, this Second Edition of the seminal Clinical Trials Dictionary goes well beyond general medical dictionaries in representing the large and complex vocabulary needed to describe the methods and results of clinical trials. It provides a thorough index to the entries of its main section-facilitating the findings of terms associated with particular concepts and practical steps in trials; over 300 new "usage notes"; and biographical notes on prominent historical personalities and institutions.

CURTIS L. MEINERT, PhD, is Professor in the Departments of Epidemiology and Biostatistics at the Johns Hopkins Bloomberg School of Public Health, where he served as founder of the Johns Hopkins Center for Clinical Trials. He is a Fellow of the American College of Epidemiology, the American Association for the Advancement of Science, the American Heart Association, and the Society for Clinical Trials. Dr. Meinert has focused his research on the methodological issues in clinical trials, including their design, conduct, policy, and practice. He is the author of Clinical Trials Handbook: Design and Conduct (Wiley).

FOREWORD 1ST EDITION ix

PREFACE xi

CONTRIBUTORS xiii

EXPLANATORY NOTES xv

Domain of coverage xv
Order and place of entries xv
Synonyms, antonyms, and related terms xv
Language and usage conventions xv
Sources and references xvi
Adages xvi
Usage notes xvi
Etymologies xvi
Abbreviations xvii
Index xvii

USAGE PRACTICES, CAUTIONS, AND RECOMMENDATIONS xix

ABBREVIATIONS xli

LISTING OF ENTRIES xlvii
Dictionary
A 1
B 15
C 27
D 63
E 79
F 93
G 107
H 113
I 119
J and K 137
L 141
M 151
N 165
O 175
P 185
Q 217
R 221
S 241
T 273
U 291
V 297
W 301
X, Y, and Z 305

REFERENCES 307

INDEX 317

EQUATIONS AND FUNCTIONS

Bayes' theorem 18
Binomial distribution 22
Binomial theorem 22
Bivariate normal distribution 23
Exponential distribution 90
F-test statistic 93
Gamma distribution 107
Gamma function 107
Geometric distribution 108
Gompertz's curve 108
Greco-Latin square 110
Hypergeometric distribution 117
Inverse sine transformation 133
Kappa statistic 138
Kendall’s tau 139
Latin square 141
Normal distribution 172
Poisson distribution 199
Square root transformation 256
t distribution 273

GRAPHIC ILLUSTRATIONS

Figure 1. Bar Diagram 16
Figure 2. Bell-Shaped Curve 18
Figure 3. Bimodal Distribution 21
Figure 4. Box Plot 25
Figure 5. Chi-square Distribution 31
Figure 6. Circle Graph 32
Figure 7. Closed Sequential Design 37
Figure 8. CONSORT Chart 52
Figure 9. Cumulative Frequency Distribution 60
Figure 10. Exponential Distribution 90
Figure 11. F Distribution 93
Figure 12. Flowchart 99
Figure 13. Forest Plot 101
Figure 14. Frequency Polygon 103
Figure 15. Gantt Chart 107
Figure 16. Histogram 116
Figure 17. Isometric Graph 136
Figure 18. J-shaped Curve 137
Figure 19. Left Skew Distribution 143
Figure 20. Logistic Curve 147
Figure 21. Normal Distribution 172
Figure 22. Open Sequential Design 180
Figure 23. Poisson Distribution 199
Figure 24. Right Skew Distribution 239
Figure 25. s-shaped Curve 241
Figure 26. Scatter Diagram 243
Figure 27. Survival Curve 270
Figure 28. t Distribution 273
Figure 29. Uniform Distribution 294
Figure 30. Venn Diagram 299

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Clinical Trials Dictionary Terminology and Usage Recommendations

Clinical Trials Dictionary Terminology and Usage Recommendations

1118295153

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