Formerly "Clinical Pharmacokinetics: Concepts and Clinical Applications, " this fully updated Fourth Edition has been retitled "Pharmacokinetics and Pharmacodynamics: Concepts and Clinical Applications" to reflect the increasing body of knowledge linking the two concepts that explain the relationship between drug administration and drug response. This revised edition also reflects the explosion in our understanding at the molecular and mechanistic levels of all the processes controlling the pharmacokinetics of drugs. The text is authored by two leading international experts on the clinical aspects of pharmacokinetics/pharmacodynamics and is widely considered one of the authoritative texts on the subject.