Across education, out-of-school-time programming, and workforce development, researchers and practitioners are seeking ways to bolster the career readiness of our nation's youth, particularly low-income youth. This issue brings together information from a variety of disciplines and fields to help researchers, practitioners, and policymakers understand what we know and need to learn to provide youth with effective, engaging career-related programming. The articles highlight key findings about how youth learn about careers and develop a vocational identity, whether adolescent employment is beneficial for youth, and how to align our various systems to promote positive youth development. Models of career programming from education, afterschool, and workforce development are highlighted, as are strategies for collaborating with businesses. The volume emphasizes the practical implications of research findings, keeping the focus on how to develop evidence-based practices to support career development for youth.