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Genetics : From Genes to Genomes

by: Hartwell, Leland; Hood, Leroy; Goldberg, Michael L.; Reynolds, Ann; Silver, Lee M.

Genetics : From Genes to Genomes

by: Hartwell, Leland; Hood, Leroy; Goldberg, Michael L.; Reynolds, Ann; Silver, Lee M.

ISBN 13:
9780073227382
ISBN 10:
0073227382
Edition: 3rd
Format: Hardcover
Copyright: 10/09/2006
Publisher: McGraw-Hill Science/Engineering/Math
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Summary

Genetics: From Genes to Genomesis a cutting-edge, introductory genetics text authored by an unparalleled author team, including Nobel Prize winner, Leland Hartwell. The Third Edition continues to build upon the integration of Mendelian and molecular principles, providing students with the links between early genetics understanding and the new molecular discoveries that have changed the way the field of genetics is viewed.

About the Authors

iii

Preface

Acknowledgements

xxi

Genetics: The Study of Biological Information

(12)

The Biological Information Fundamental to Life is Encoded in the DNA Molecule

(2)

Biological Function Emerges Primarily from Protein Molecules

(1)

Complex Systems Arise from DNA-Protein and Protein-Protein Interactions

(1)

All Living Things Are Closely Related at the Molecular Level

(2)

The Modular Construction of Genomes Has Allowed the Rapid Evolution of Complexity

(1)

Genetic Techniques Permit the Dissection of Complexity

(2)

Our Focus Is on Human Genetics

(3)

PART I Basic Principles: How Traits Are Transmitted

(154)

Mendel's Breakthrough: Patterns, Particles, and Principles of Heredity

(32)

Background: The Historical Puzzle of Inheritance

(4)

Genetic Analysis According to Mendel

(11)

Mendelian Inheritance in Humans: Two Comprehensive Examples

(15)

Fast Forward

(6)

Tools of Genetics

(6)

Genetics and Society

(11)

Extensions to Mendel: Complexities in Relating Genotype to Phenotype

(36)

Extensions to Mendel for Single-Gene Inheritance

(10)

Extensions to Mendel for Multifactorial Inheritance

(25)

Fast Forward

(11)

Genetics and Society

(13)

The Chromosome Theory of Inheritance

(42)

Chromosomes Contain the Genetic Material

(6)

Mitosis Ensures That Every Cell in an Organism Carries the Same Chromosomes

(5)

Meiosis Produces Haploid Germ Cells, the Gametes

(10)

Gametogenesis Requires Both Mitotic and Meiotic Divisions

103

(2)

Validation of the Chromosome Theory

105

(18)

Genetics and Society

(8)

Fast Forward

(28)

Linkage, Recombination, and the Mapping of Genes on Chromosomes

123

(44)

Gene Linkage and Recombination

124

(11)

Mapping: Locating Genes Along a Chromosome

135

(17)

Mitotic Recombination Can Produce Genetic Mosaics

152

(15)

Tools of Genetics

128

(14)

Fast Forward

142

(12)

Genetics and Society

154

(13)

PART II What Genes Are and What They Do

167

(134)

DNA: How the Molecule of Heredity Carries, Replicates, and Recombines Information

167

(40)

Experiments Designate DNA as the Genetic Material

168

(5)

The Watson-Crick Model: DNA Is a Double Helix

173

(7)

DNA Stores Information in the Sequence of Its Bases

180

(4)

DNA Replication: Copying Genetic Information for Transmission to the Next Generation

184

(7)

Recombination Reshuffles the Information Content of DNA

191

(16)

Tools of Genetics

182

(25)

Anatomy and Function of a Gene: Dissection Through Mutation

207

(48)

Mutations: Primary Tools of Genetic Analysis

208

(16)

What Mutations Tell Us About Gene Structure

224

(8)

What Mutations Tell Us About Gene Function

232

(7)

How Gene Mutations Affect Light-Receiving Proteins and Vision: A Comprehensive Example

239

(16)

Genetics and Society

216

(24)

Fast Forward

240

(15)

Gene Expression: The Flow of Genetic Information from DNA to RNA to Protein

255

(46)

The Genetic Code: How Precise Groupings of the Four Nucleotides Specify 20 Amino Acids

257

(8)

Transcription: RNA Polymerase Synthesizes a Single-Stranded RNA Copy of a Gene

265

(10)

Translation: Base Pairing Between mRNA and tRNAs Directs Assembly of a Polypeptide on the Ribosome

275

(7)

There Are Significant Differences in Gene Expression Between Prokaryotes and Eukaryotes

282

(2)

Comprehensive Example: A Computerized Analysis of Gene Expression in C. elegans

284

(1)

How Mutations Affect Gene Expression and Gene Function

285

(16)

Genetics and Society

270

(31)

PART III Genomes

301

(164)

Deconstructing the Genome: DNA at High Resolution

301

(50)

Fragmenting Complex Genomes into Bite-Size Pieces for Analysis

303

(7)

Cloning Fragments of DNA

310

(9)

Hybridization Is Used to Identify Similar DNA Sequences

319

(8)

The Polymerase Chain Reaction Provides a Rapid Method for Isolating DNA Fragments

327

(3)

DNA Sequence Analysis

330

(5)

Understanding the Genes for Hemoglobin: A Comprehensive Example

335

(16)

Tools of Genetics

306

(14)

Genetics and Society

320

(31)

Reconstructing the Genome Through Genetic and Molecular Analysis

351

(40)

Analyses of Genomes

354

(12)

Major Insights from the Human and Model Organism Genome Sequences

366

(9)

High-Throughput Genomic Platforms Permit the Global Analysis of Genes and Their mRNAs

375

(16)

Genetics and Society

381

(10)

The Direct Detection of Genotype Distinguishes Individual Genomes

391

(46)

DNA Variation Is Multifaceted and Widespread

394

(5)

Detecting DNA Genotypes of Different Types of Polymorphisms

399

(9)

Positional Cloning: From DNA Markers to Gene Clones

408

(11)

Genetic Dissection of Complex Traits

419

(4)

Haplotype Association Studies for High-Resolution Mapping in Humans

423

(14)

Genetics and Society

394

(22)

Tools of Genetics

416

(21)

Systems Biology and Proteomics

437

(28)

What Is Systems Biology?

439

(1)

Looking at Biology as an Informational Science Is Central to the Practice of Systems Biology

440

(4)

Global Proteomics Strategies and High-Throughput Platforms Make It Possible to Gather and Analyze Systemwide Protein Data

444

(7)

Putting It All Together: The Practice of Systems Biology

451

(4)

A Systems Approach to Disease Leads to Predictive, Preventive, and Personalized Medicine

455

(10)

Genetics and Society

457

(8)

PART IV How Genes Travel on Chromosomes

465

(144)

The Eukaryotic Chromosome: An Organelle for Packaging and Managing DNA

465

(24)

The Components of Eukaryotic Chromosomes: DNA, Histones, and Nonhistone Proteins

466

(3)

Chromosome Structure: Variable DNA-Protein Interactions Create Reversible Levels of Compaction

469

(5)

Specialized Chromosomal Elements Ensure Accurate Replication and Segregation of Chromosomes

474

(5)

How Chromosomal Packaging Influences Gene Activity

479

(10)

Chromosomal Rearrangements and Changes in Chromosome Number Reshape Eukaryotic Genomes

489

(50)

Rearrangements of DNA Sequences Within Chromosomes

491

(25)

Changes in Chromosome Number

516

(8)

A Glimpse of the Future: Emergent Technologies in the Analysis of Chromosomal Rearrangements and Changes in Chromosome Number

524

(15)

Fast Forward

492

(47)

The Prokaryotic Chromosome: Genetic Analysis in Bacteria

539

(42)

A General Overview of Prokaryotes

540

(3)

The Bacterial Genome

543

(7)

Gene Transfer in Bacteria

550

(16)

Comprehensive Example: Genetic Dissection Helps Explain How Bacteria Move

566

(4)

Genome Analysis Provides Powerful New Tools for Understanding Bacteria

570

(11)

Genetics and Society

544

(37)

The Chromosomes of Organelles Outside the Nucleus Exhibit Non-Mendelian Patterns of Inheritance

581

(28)

The Structure and Function of Mitochondrial and Chloroplast Genomes

583

(9)

Genetic Studies of Organelle Genomes Clarify Key Elements of Non-Mendelian Inheritance

592

(7)

Comprehensive Example: How Mutations in mtDNA Affect Human Health

599

(10)

Fast Forward

594

(6)

Genetics and Society

600

(9)

PART V How Genes Are Regulated

609

(148)

Gene Regulation in Prokaryotes

609

(34)

An Overview of Prokaryotic Gene Regulation

611

(1)

The Regulation of Gene Transcription

612

(14)

The Attenuation of Gene Expression: Fine-Tuning the trp Operon Through the Termination of Transcription

626

(2)

Global Regulatory Mechanisms Coordinate the Expression of Many Sets of Genes

628

(4)

A Comprehensive Example: The Regulation of Virulence Genes in V. cholerae

632

(11)

Genetics and Society

630

(13)

Gene Regulation in Eukaryotes

643

(42)

The Use of Genetics to Study Gene Regulation

645

(1)

Gene Regulation Begins with Control Over the Initiation of Transcription

646

(18)

Regulation After Transcription Influences RNA Production, Protein Synthesis, and Protein Stability

664

(5)

Sex Determination in Drosophila: A Comprehensive Example of Gene Regulation

669

(16)

Tools of Genetics

670

(15)

Cell-Cycle Regulation and the Genetics of Cancer

685

(32)

The Normal Control of Cell Division

686

(10)

Cancer Arises When Controls Over Cell Division No Longer Function Properly

696

(21)

Using Genetics to Study Development

717

(40)

Model Organisms: Prototypes for Developmental Genetics

719

(2)

Genetics Simplifies the Study of Development

721

(11)

The Genetic Analysis of Body-Plan Development in Drosophila: A Comprehensive Example

732

(13)

How Genes Help Control Development: A Mechanistic Framework

745

(12)

Genetics and Society

724

(33)

PART VI How Genes Change

757

The Genetic Analysis of Populations and How They Evolve

757

(34)

The Hardy-Weinberg Law: A Model for Understanding Allele, Genotype, and Phenotype Frequencies for a Single-Gene Trait in a Genetically Stable Population

759

(3)

Beyond Hardy-Weinberg: Measuring How Mutation and Selection Cause Changes in Allele Frequencies

762

(11)

Analyzing the Quantitative Variation of Multifactorial Traits

773

(18)

Genetics and Society

780

(11)

Evolution at the Molecular Level

791

The Origin of Life on Earth

794

(5)

The Evolution of Genomes

799

(6)

The Organization of Genomes

805

(8)

The Immunoglobulin Gene Superfamily: A Comprehensive Example of Molecular Evolution

813

Genetics and Society

802

Guidelines for Gene Nomenclature

(1)

Brief Answer Section

(1)

Glossary

(1)

Credits

(1)

Index

Amazon no longer offers textbook rentals. We do!

Genetics : From Genes to Genomes

Genetics : From Genes to Genomes

9780073227382

0073227382

Summary

Table of Contents

Supplemental Materials

Write a Review

Amazon no longer offers textbook rentals. We do!

Genetics : From Genes to Genomes

Genetics : From Genes to Genomes

9780073227382

0073227382

Summary

Table of Contents

Supplemental Materials

Write a Review

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