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Harrison's Principles of Internal Medicine

ISBN: 9780070202917 | 0070202915
Edition: 14th
Format: Hardcover
Publisher: McGraw-Hill Incorporated
Pub. Date: 8/1/1997

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SummaryTable of Contents
Classic text for practitioners, residents, and students.
Contributorsxv
PrefaceXXV
Part One INTRODUCTION TO CLINICAL MEDICINE
The Practice of Medicine
1(5)
The Edi... MORE
Ethical Issues in Clinical Medicine
6(3)
Bernard Lo
Quantitative Aspects of Clinical Reasoning
9(5)
Lee Goldman
Host and Disease: Influence of Demographic and Socioeconomic Factors
14(4)
Virginia L. Ernster
John M. Colford, Jr.
Influence of Environmental and Occupational Hazards on Disease
18(3)
Howard Hu
Frank E. Speizer
Women's Health
21(3)
Anthony L. Komaroff
Celeste Robb-Nicholson
Beverly Woo
Medical Disorders during Pregnancy
24(6)
Thomas F. Ferris
Adolescent Health Problems
30(7)
Charles E. Irwin, Jr.
Mary-Ann Shafer
Geriatric Medicine
37(9)
Neil M. Resnick
Principles of Disease Prevention
46(3)
Maureen T. Connelly
Thomas S. Inui
Cost Awareness in Medicine
49(4)
Lee Goldman
Part Two CARDINAL MANIFESTATIONS AND PRESENTATION OF DISEASES
Section 1 Pain
Pain: Pathophysiology and Management
53(5)
Howard L. Fields
Joseph B. Martin
Chest Discomfort and Palpitation
58(7)
Lee Goldman
Abdominal Pain
65(3)
William Silen
Headache
68(5)
Neil H. Raskin
Back and Neck Pain
73(11)
John W. Engstrom
David S. Bradford
Section 2 Alterations in Body Temperature
Fever and Hyperthermia
84(6)
Jeffrey A. Gelfand
Charles A. Dinarello
Fever and Rash
90(7)
Elaine T. Kaye
Kenneth M. Kaye
Hypothermia
97(3)
Kevin J. Petty
Section 3 Nervous System Dysfunction
Faintness, Syncope, Dizziness, and Vertigo
100(7)
Robert B. Daroff
Joseph B. Martin
Weakness, Abnormal Movements, and Imbalance
107(11)
Richard K. Olney
Michael J. Aminoff
Episodic Muscle Spasms, Cramps, and Weakness
118(4)
Robert C. Griggs
Numbness, Tingling, and Sensory Loss
122(3)
Arthur K. Asbury
Acute Confusional States and Coma
125(9)
Allan H. Ropper
Joseph B. Martin
Aphasias and Other Focal Cerebral Disorders
134(8)
M.-Marsel Mesulam
Memory Loss and Dementia
142(8)
Thomas D. Bird
Disorders of Sleep and Circadian Rhythms
150(9)
Charles A. Czeisler
Gary S. Richardson
Section 4 Disorders of Eyes, Ears, Nose, and Throat
Disorders of the Eye
159(14)
Jonathan C. Horton
Disorders of Smell, Taste, and Hearing
173(6)
James B. Snow, Jr.
Joseph B. Martin
Infections of the Upper Respiratory Tract
179(6)
Marlene Durand
Michael Joseph
Ann Sullivan Baker
Oral Manifestations of Disease
185(5)
John S. Greenspan
Section 5 Alterations in Circulatory and Respiratory Functions
Dyspnea and Pulmonary Edema
190(4)
Roland H. Ingram, Jr.
Eugene Braunwald
Cough and Hemoptysis
194(4)
Steven E. Weinberger
Eugene Braunwald
Approach to the Patient with a Heart Murmur
198(4)
Patrick T. O'Gara
Eugene Braunwald
Approach to the Patient with Hypertension
202(3)
Gordon H. Williams
Hypoxia, Polycythemia, and Cyanosis
205(5)
Eugene Braunwald
Edema
210(4)
Eugene Braunwald
Shock
214(8)
Steven M. Hollenberg
Joseph E. Parrillo
Cardiovascular Collapse, Cardiac Arrest, and Sudden Cardiac Death
222(6)
Robert J. Myerburg
Agustin Castellanos
Section 6 Alterations in Gastrointestinal Function
Dysphagia
228(2)
Raj K. Goyal
Nausea, Vomiting, and Indigestion
230(6)
Lawrence S. Friedman
Kurt J. Isselbacher
Diarrhea and Constipation
236(8)
Lawrence S. Friedman
Kurt J. Isselbacher
Gain and Loss in Weight
244(2)
Daniel W. Foster
Gastrointestinal Bleeding
246(3)
Alan Epstein
Kurt J. Isselbacher
Jaundice
249(6)
Lee M. Kaplan
Kurt J. Isselbacher
Abdominal Swelling and Ascites
255(3)
Robert M. Glickman
Kurt J. Isselbacher
Section 7 Alterations in Urinary Function and Electrolytes
Cardinal Manifestations of Renal Disease
258(4)
Bradley M. Denker
Barry M. Brenner
Voiding Dysfunction, Incontinence, and Bladder Pain
262(3)
Philippe E. Zimmern
John D. McConnell
Fluid and Electrolyte Disturbances
265(12)
Gary G. Singer
Barry M. Brenner
Acidosis and Alkalosis
277(9)
Thomas D. DuBose, Jr.
Section 8 Alterations in the Urogenital Tract
Impotence
286(3)
John D. McConnell
Jean D. Wilson
Disturbances of Menstruation and Other Common Gynecologic Complaints in Women
289(3)
Bruce R. Carr
Karen D. Bradshaw
Hirsutism and Virilization
292(2)
William J. Kovacs
Jean D. Wilson
Section 9 Alterations in the Skin
Approach to the Patient with Skin Disorders
294(4)
Thomas J. Lawley
Kim B. Yancey
Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin Disorders
298(6)
Robert A. Swerlick
Thomas J. Lawley
Cutaneous Drug Reactions
304(6)
Bruce U. Wintroub
Robert S. Stern
Skin Manifestations of Internal Disease
310(18)
Jean L. Bolognia
Irwin M. Braverman
Photosensitivity and Other Reactions to Light
328(6)
David R. Bickers
Section 10 Hematologic Alterations
Anemia
334(5)
Robert S. Hillman
Bleeding and Thrombosis
339(6)
Robert I. Handin
Enlargement of Lymph Nodes and Spleen
345(6)
Patrick H. Henry
Dan L. Longo
Disorders of Granulocytes and Monocytes
351(9)
Steven M. Holland
John I. Gallin
Section 11 Manifestations of Cancer
Presentations of the Patient with Cancer: Solid Tumors in Adults
360(2)
Daniel C. Ihde
Dan L. Longo
Evaluation of Breast Masses in Men and Women
362(3)
Marc E. Lippman
Part Three GENETICS AND DISEASE
Genetics and Disease
365(30)
Arthur L. Beaudet
Cytogenetic Aspects of Human Disease
395(8)
James German
Treatment and Prevention of Genetic Disease
403(8)
David Valle
Part Four CLINICAL PHARMACOLOGY
Principles of Drug Therapy
411(11)
John A. Oates
Grant R. Wilkinson
Adverse Reactions to Drugs
422(8)
Alastair J. J. Wood
Physiology and Pharmacology of the Autonomic Nervous System
430(12)
Lewis Landsberg
James B. Young
Nitric Oxide: Biologic and Medical Implications
442(3)
Joseph Loscalzo
Part Five NUTRITION
Nutrition and Nutritional Requirements
445(3)
Margo Denke
Jean D. Wilson
Assessment of Nutritional Status
448(4)
Margo Denke
Jean D. Wilson
Protein and Energy Malnutrition
452(2)
Margo Denke
Jean D. Wilson
Obesity
454(8)
George A. Bray
Anorexia Nervosa and Bulimia Nervosa
462(3)
Daniel W. Foster
Diet Therapy
465(7)
Chery L. Rock
Ann M. Coulston
Mack T. Ruffin IV
Enteral and Parenteral Nutrition Therapy
472(8)
Lyn Howard
Vitamin Deficiency and Excess
480(9)
Jean D. Wilson
Disturbances in Trace Elements
489(4)
Kenneth H. Falchuk
Part Six ONCOLOGY AND HEMATOLOGY
Section 1 Neoplastic Disorders
Approach to the Patient with Cancer
493(6)
Dan L. Longo
Prevention and Early Detection of Cancer
499(6)
Otis W. Brawley
Barnett S. Kramer
Cell Biology of Cancer
505(7)
Robert G. Fenton
Dan L. Longo
Cancer Genetics
512(8)
Francis S. Collins
Jeffrey M. Trent
Invasion and Metastasis
520(3)
Elise C. Kohn
Lance A. Liotta
Principles of Cancer Therapy
523(14)
Christopher A. Slapak
Donald W. Kufe
Infections in Patients with Cancer
537(6)
Robert Finberg
Melanoma and Other Skin Cancers
543(6)
Arthur J. Sober
Howard K. Koh
Nhu-Linh T. Tran
Carl V. Washington, Jr.
Head and Neck Cancer
549(3)
Everett E. Vokes
Neoplasms of the Lung
552(10)
John D. Minna
Breast Cancer
562(6)
Marc E. Lippman
Gastrointestinal Tract Cancer
568(10)
Robert J. Mayer
Tumors of the Liver and Biliary Tract
578(3)
Kurt J. Isselbacher
Jules L. Dienstag
Pancreatic Cancer
581(3)
Robert J. Mayer
Endocrine Tumors of the Gastrointestinal Tract and Pancreas
584(8)
Lee M. Kaplan
Bladder and Renal Cell Cancer
592(4)
Howard I. Scher
Robert J. Motzer
Hyperplasia and Carcinoma of the Prostate
596(6)
Arthur I. Sagalowsky
Jean D. Wilson
Testicular Cancer
602(3)
Robert J. Motzer
George J. Bosl
Gynecologic Malignancies
605(6)
Robert C. Young
Sarcomas of Soft Tissue and Bone
611(3)
Shreyaskumar R. Patel
Robert S. Benjamin
Metastatic Cancer of Unknown Primary Site
614(4)
Richard M. Stone
Paraneoplastic Syndromes
618(4)
Bruce E. Johnson
Paraneoplastic Neurologic Syndromes
622(5)
Robert H. Brown, Jr.
Oncologic Emergencies
627(7)
Rasim Gucalp
Janice Dutcher
Section 2 Disorders of Hematopoiesis
Hematopoiesis
634(4)
Francis W. Ruscetti
Jonathan R. Keller
Dan L. Longo
Iron Deficiency and Other Hypoproliferative Anemias
638(7)
Robert S. Hillman
Disorders of Hemoglobin
645(8)
Ernest Beutler
Megaloblastic Anemias
653(6)
Bernard M. Babior
H. Franklin Bunn
Hemolytic Anemias and Acute Blood Loss
659(13)
Wendell Rosse
H. Franklin Bunn
Aplastic Anemia and Myelodysplasia
672(7)
Hugo Castro-Malaspina
Richard J. O'Reilly
Polycythemia Vera and Other Myeloproliferative Diseases
679(5)
Jerry L. Spivak
Acute and Chronic Myeloid Leukemias
684(11)
Meir Wetzler
Clara D. Bloomfield
Malignancies of Lymphoid Cells
695(17)
Arnold S. Freedman
Lee M. Nadler
Plasma Cell Disorders
712(6)
Dan L. Longo
Transfusion Biology and Therapy
718(6)
Jeffery S. Dzieczkowski
Kenneth C. Anderson
Bone Marrow Transplantation
724(6)
James O. Armitage
Section 3 Disorders of Hemostasis
Disorders of the Platelet and Vessel Wall
730(6)
Robert I. Handin
Disorders of Coagulation and Thrombosis
736(8)
Robert I. Handin
Anticoagulant, Fibrinolytic, and Antiplatelet Therapy
744(5)
Robert I. Handin
Part Seven INFECTIOUS DISEASES
Section 1 Basic Considerations in Infectious Diseases
Introduction to Infectious Diseases: Host-Parasite Interaction
749(5)
Lawrence C. Madoff
Dennis L. Kasper
Laboratory Diagnosis of Infectious Diseases
754(4)
Andrew B. Onderdonk
Immunization Principles and Vaccine Use
758(14)
Gerald T. Keusch
Kenneth J. Bart
Health Risks to Travelers
772(4)
J. S. Keystone
P. E. Kozarsky
Section 2 Clinical Syndromes---Community Acquired
Sepsis and Septic Shock
776(4)
Robert S. Munford
Fever of Unknown Origin
780(5)
Jeffrey A. Gelfand
Charles A. Dinarello
Infective Endocarditis
785(7)
Donald Kaye
Intraabdominal Infections and Abscesses
792(4)
Dori F. Zaleznik
Dennis L. Kasper
Acute Infectious Diarrheal Diseases and Bacterial Food Poisoning
796(5)
Joan R. Butterton
Stephen B. Calderwood
Sexually Transmitted Diseases: Overview and Clinical Approach
801(11)
King K. Holmes
H. Hunter Handsfield
Pelvic Inflammatory Disease
812(5)
King K. Holmes
Urinary Tract Infections and Pyelonephritis
817(7)
Walter E. Stamm
Osteomyelitis
824(3)
James H. Maguire
Infections of the Skin, Muscle, and Soft Tissues
827(4)
Dennis L. Stevens
Infections (Excluding AIDS) in Injection Drug Users
831(4)
Gerald H. Friedland
Peter A. Selwyn
Infections from Bites, Scratches, and Burns
835(5)
Lawrence C. Madoff
Section 3 Clinical Syndromes---Nosocomial Infections
Infections in Transplant Recipients
840(6)
Robert Finberg
Joyce Fingeroth
Hospital-Acquired and Intravascular Device-Related Infections
846(3)
Dori F. Zaleznik
Infection Control in the Hospital
849(3)
Robert A. Weinstein
Section 4 Bacterial Diseases: General Considerations
Molecular Mechanisms of Bacterial Pathogenesis
852(4)
Gerald B. Pier
Treatment and Prophylaxis of Bacterial Infections
856(13)
Gordon L. Archer
Ronald E. Polk
Section 5 Diseases Caused by Gram-Positive Bacteria
Pneumococcal Infections
869(6)
Daniel M. Musher
Staphylococcal Infections
875(10)
Robert L. Deresiewicz
Jeffrey Parsonnet
Streptococcal and Enterococcal Infections
885(7)
Michael R. Wessels
Diphtheria, Other Corynebacterial Infections, and Anthrax
892(7)
Randall K. Holmes
Infections Caused by Listeria monocytogenes
899(2)
Anne Schuchat
Claire V. Broome
Tetanus
901(3)
Elias Abrutyn
Botulism
904(2)
Elias Abrutyn
Gas Gangrene, Antibiotic-Associated Colitis, and Other Clostridial Infections
906(4)
Dennis L. Kasper
Dori F. Zaleznik
Section 6 Diseases Caused by Gram-Negative Bacteria
Meningococcal Infections
910(5)
Claus O. Solberg
Gonococcal Infections
915(7)
King K. Holmes
Stephen A. Morse
Moraxella (Branhamella) catarrhalis, Other Moraxella Species, and Kingella
922(2)
Daniel M. Musher
Infections due to Haemophilus influenzae, Other Haemophilus Species, the HACEK Group, and Other Gram-Negative Bacilli
924(4)
Timothy F. Murphy
Dennis L. Kasper
Legionella Infection
928(5)
Lutfiye Mulazimoglu
Victor L. Yu
Pertussis
933(3)
George R. Siber
Matthew H. Samore
Diseases Caused by Gram-Negative Enteric Bacilli
936(5)
Barry I. Eisenstein
Vish Watkins
Helicobacter Infections
941(2)
John C. Atherton
Martin J. Blaser
Infections due to Pseudomonas Species and Related Organisms
943(7)
Matthew Pollack
Salmonellosis
950(7)
Gerald T. Keusch
Shigellosis
957(3)
Gerald T. Keusch
Infections due to Campylobacter and Related Species
960(2)
Martin J. Blaser
Cholera and Other Vibrioses
962(7)
Gerlad T. Keusch
Robert L. Deresiewicz
Brucellosis
969(2)
M. Monir Madkour
Tularemia
971(4)
Richard F. Jacobs
Plague and Other Yersinia Infections
975(8)
Grant L. Campbell
David T. Dennis
Bartonella Infections, Including Cat-Scratch Disease
983(3)
Lucy Stuart Tompkins
Donovanosis (Granuloma Inguinale)
986(1)
King K. Holmes
Section 7 Miscellaneous Bacterial Infections
Nocardiosis
987(2)
Gregory A. Filice
Actinomycosis
989(2)
Thomas A. Russo
Infections due to Mixed Anaerobic Organisms
991(6)
Dennis L. Kasper
Section 8 Mycobacterial Diseases
Antimycobacterial Agents
997(7)
Paul W. Wright
Richard J. Wallace, Jr.
Tuberculosis
1004(10)
Mario C. Raviglione
Richard J. O'Brien
Leprosy (Hansen's Disease)
1014(5)
Richard A. Miller
Infections due to Nontuberculous Mycobacteria
1019(4)
Bernard Hirschel
Section 9 Spirochetal Diseases
Syphilis
1023(10)
Sheila A. Lukehart
King K. Holmes
Endemic Treponematoses
1033(3)
Peter L. Perine
Leptospirosis
1036(2)
Peter Speelman
Relapsing Fever
1038(4)
David T. Dennis
Grant L. Campbell
Lyme Borreliosis
1042(3)
Allen C. Steere
Section 10 Rickettsia, Mycoplasma, and Chlamydia
Rickettsial Diseases
1045(7)
David Walker
Didier Raoult
Philippe Brouqui
Thomas Marrie
Mycoplasma Infections
1052(3)
Gail H. Cassell
Gregory C. Gray
K. B. Waites
Chlamydial Infections
1055(10)
Walter E. Stamm
Section 11 Viral Diseases
Medical Virology
1065(7)
Fred Wang
Elliott Kieff
Antiviral Chemotherapy
1072(8)
Raphael Dolin
Section 12 DNA Viruses
Herpes Simplex Viruses
1080(6)
Lawrence Corey
Varicella-Zoster Virus Infections
1086(3)
Richard J. Whitley
Epstein-Barr Virus Infections, Including Infectious Mononucleosis
1089(3)
Jeffrey I. Cohen
Cytomegalovirus and Human Herpesvirus Types 6, 7, and 8
1092(3)
Martin S. Hirsch
Smallpox, Vaccinia, and Other Poxviruses
1095(1)
Fred Wang
Parvovirus
1096(2)
Neil R. Blacklow
Human Papillomavirus Infections
1098(2)
Richard C. Reichman
Section 13 DNA and RNA Respiratory Viruses
Common Viral Respiratory Infections
1100(5)
Raphael Dolin
Section 14 RNA Viruses
The Human Retroviruses
1105(7)
Anthony S. Fauci
Dan L. Longo
Influenza
1112(4)
Raphael Dolin
Viral Gastroenteritis
1116(2)
Harry B. Greenberg
Enteroviruses and Reoviruses
1118(5)
Jeffrey I. Cohen
Measles (Rubeola)
1123(2)
Anne Gershon
Rubella (German Measles)
1125(2)
Anne Gershon
Mumps
1127(1)
Anne Gershon
Rabies Virus and Other Rhabdoviruses
1128(4)
Lawrence Corey
Infections Caused by Arthropod-and Rodent-Borne Viruses
1132(14)
C. J. Peters
Marburg and Ebola Viruses (Filoviridae)
1146(2)
Lawrence Corey
Section 15 Fungal Infections
Diagnosis and Treatment of Fungal Infections
1148(2)
John E. Bennett
Histoplasmosis
1150(1)
John E. Bennett
Coccidioidomycosis
1151(1)
John E. Bennett
Blastomycosis
1152(1)
John E. Bennett
Cryptococcosis
1153(1)
John E. Bennett
Candidiasis
1154(2)
John E. Bennett
Aspergillosis
1156(2)
John E. Bennett
Mucormycosis
1158(1)
John E. Bennett
Miscellaneous Mycoses and Prototheca Infections
1158(3)
John E. Bennett
Pneumocystis carinii Infection
1161(2)
Peter D. Walzer
Section 16 Protozoal and Helminthic Infections: General Considerations
Approach to the Patient with Parasitic Infections
1163(2)
Peter F. Weller
Laboratory Diagnosis of Parasitic Infections
1165(6)
Charles E. Davis
Therapy for Parasitic Infections
1171(5)
Leo X. Liu
Peter F. Weller
Section 17 Protozoal Infections
Amebiasis and Infection with Free-Living Amebas
1176(4)
Sharon L. Reed
Malaria and Other Diseases Caused by Red Blood Cell Parasites
1180(9)
Nicholas J. White
Joel G. Breman
Leishmaniasis
1189(4)
Barbara L. Herwaldt
Trypanosomiasis
1193(4)
Louis V. Kirchhoff
Toxoplasma Infection
1197(5)
Lloyd H. Kasper
Protozoal Intestinal Infections and Trichomoniasis
1202(4)
Theodore E. Nash
Peter F. Weller
Section 18 Helminthic Infections
Trichinosis and Infections with Other Tissue Nematodes
1206(2)
Leo X. Liu
Peter F. Weller
Intestinal Nematodes
1208(4)
Leo X. Liu
Peter F. Weller
Filariasis and Related Infections (Loiasis, Onchocerciasis, and Dracunculiasis)
1212(5)
Thomas B. Nutman
Peter F. Weller
Schistosomiasis and Other Trematode Infections
1217(7)
Theodore E. Nash
Cestodes
1224(5)
Thomas B. Nutman
Peter F. Weller
Part Eight DISORDERS OF THE CARDIOVASCULAR SYSTEM
Section 1 Diagnosis
Approach to the Patient with Heart Disease
1229(2)
Eugene Braunwald
Physical Examination of the Cardiovascular System
1231(6)
Robert A. O'Rourke
Eugene Braunwald
Electrocardiography
1237(10)
Ary L. Goldberger
Diagnostic Cardiac Catheterization and Angiography
1247(6)
Donald S. Baim
William Grossman
Section 2 Disorders of Rhythm
The Bradyarrhythmias: Disorders of Sinus Node Function and AV Conduction Disturbances
1253(8)
mark E. Josephson
Peter Zimetbaum
Francis E. Marchlinski
Alfred E. Buxton
The Tachyarrhythmias
1261(17)
Mark E. Josephson
Peter Zimetbaum
Alfred E. Buxton
Francis E. Marchlinski
Section 3 Disorders of the Heart
Normal and Abnormal Myocardial Function
1278(9)
Eugene Braunwald
Heart Failure
1287(11)
Eugene Braunwald
Cardiac Transplantation
1298(2)
John S. Schroeder
Congenital Heart Disease in the Adult
1300(9)
William F. Friedman
John S. Child
Rheumatic Fever
1309(2)
Edward L. Kaplan
Valvular Heart Disease
1311(13)
Eugene Braunwald
Cor Pulmonale
1324(4)
Eugene Braunwald
The Cardiomyopathies and Myocarditides
1328(6)
Joshua Wynne
Eugene Braunwald
Pericardial Disease
1334(7)
Eugene Braunwald
Cardiac Tumors, Cardiac Manifestations of Systemic Diseases, and Traumatic Cardiac Injury
1341(4)
Wilson S. Colucci
Eugene Braunwald
Section 4 Vascular Disease
Atherosclerosis
1345(7)
Peter Libby
Acute Myocardial Infarction
1352(13)
Elliott M. Antman
Eugene Braunwald
Ischemic Heart Disease
1365(10)
Andrew P. Selwyn
Eugene Braunwald
Coronary Angioplasty and Other Therapeutic Applications of Cardiac Catheterization
1375(5)
Donald S. Baim
William Grossman
Hypertensive Vascular Disease
1380(14)
Gordon H. Williams
Diseases of the Aorta
1394(4)
Victor J. Dzau
Mark A. Creager
Vascular Diseases of the Extremities
1398(9)
Mark A. Creager
Victor J. Dzau
Part Nine DISORDERS OF THE RESPIRATORY SYSTEM
Section 1 Diagnosis
Approach to the Patient with Disease of the Respiratory System
1407(3)
Jeffrey M. Drazen
Steven E. Weinberger
Disturbances of Respiratory Function
1410(7)
Steven E. Weinberger
Jeffrey M. Drazen
Diagnostic Procedures in Respiratory Disease
1417(2)
Steven E. Weinberger
Jeffrey M. Drazen
Section 2 Diseases of the Respiratory System
Asthma
1419(7)
E. R. McFadden, Jr.
Hypersensitivity Pneumonitis and Eosinophilic Pneumonias
1426(3)
Gary W. Hunninghake
Hal B. Richerson
Environmental Lung Diseases
1429(8)
Frank E. Speizer
Pneumonia, Including Necrotizing Pulmonary Infections (Lung Abscess)
1437(8)
Matthew E. Levison
Bronchiectasis
1445(3)
Steven E. Weinberger
Cystic Fibrosis
1448(3)
Richard C. Boucher
Chronic Bronchitis, Emphysema, and Airway Obstruction
1451(9)
Eric G. Honig
Roland H. Ingram, Jr.
Interstitial Lung Diseases
1460(6)
Herbert Y. Reynolds
Primary Pulmonary Hypertension
1466(3)
Stuart Rich
Pulmonary Thromboembolism
1469(3)
Samuel Z. Goldhaber
Disorders of the Pleura, Mediastinum, and Diaphragm
1472(4)
Richard W. Light
Disorders of Ventilation
1476(4)
Eliot A. Phillipson
Sleep Apnea
1480(3)
Eliot A. Phillipson
Acute Respiratory Distress Syndrome
1483(3)
Eric G. Honig
Roland H. Ingram, Jr.
Mechanical Ventilatory Support
1486(5)
Edward P. Ingenito
Jeffrey M. Drazen
Lung Transplantation
1491(4)
Janet R. Maurer
Part Ten DISORDERS OF THE KIDNEY AND URINARY TRACT
Approach to the Patient with Diseases of the Kidneys and Urinary Tract
1495(3)
Fredric L. Coe
Barry M. Brenner
Disturbances of Renal Function
1498(6)
Barry M. Brenner
Harald S. Mackenzie
Acute Renal Failure
1504(9)
Hugh R. Brady
Barry M. Brenner
Chronic Renal Failure
1513(7)
J. Michael Lazarus
Barry M. Brenner
Dialysis and Transplantation in the Treatment of Renal Failure
1520(9)
Charles B. Carpenter
J. Michael Lazarus
Pathogenetic Mechanisms of Glomerular Injury
1529(7)
Hugh R. Brady
Barry M. Brenner
The Major Glomerulopathies
1536(9)
Hugh R. Brady
Yvonne M. O'Meara
Barry M. Brenner
Glomerulopathies Associated with Multisystem Diseases
1545(8)
Yvonne M. O'Meara
Hugh R. Brady
Barry M. Brenner
Tubulointerstitial Diseases of the Kidney
1553(5)
Barry M. Brenner
Elliott Levy
Thomas H. Hostetter
Vascular Injury to the Kidney
1558(4)
Kamal F. Badr
Barry M. Brenner
Hereditary Tubular Disorders
1562(7)
John R. Asplin
Fredric L. Coe
Nephrolithiasis
1569(5)
John R. Asplin
Fredric L. Coe
Murray J. Favus
Urinary Tract Obstruction
1574(5)
Julian L. Seifter
Barry M. Brenner
Part Eleven DISORDERS OF THE GASTROINTESTINAL SYSTEM
Section 1 Disorders of the Alimentary Tract
Approach to the Patient with Gastrointestinal Disease
1579(4)
Kurt J. Isselbacher
Daniel K. Podolsky
Gastrointestinal Endoscopy
1583(5)
Fred E. Silverstein
Diseases of the Esophagus
1588(8)
Raj K. Goyal
Peptic Ulcer and Related Disorders
1596(20)
Lawrence S. Friedman
Walter L. Peterson
Disorders of Absorption
1616(17)
Norton J. Greenberger
Kurt J. Isselbacher
Inflammatory Bowel Disease: Ulcerative Colitis and Crohn's Disease
1633(13)
Robert M. Glickman
Irritable Bowel Syndrome
1646(2)
Richard B. Lynn
Lawrence S. Friedman
Diverticular, Vascular, and Other Disorders of the Intestine and Peritoneum
1648(8)
Kurt J. Isselbacher
Alan Epstein
Acute Intestinal Obstruction
1656(2)
William Silen
Acute Appendicitis
1658(2)
William Silen
Section 2 Liver and Biliary Tract Disease
Approach to the Patient with Liver Disease
1660(3)
Kurt J. Isselbacher
Daniel K. Podolsky
Evaluation of Liver Function
1663(4)
Daniel K. Podolsky
Kurt J. Isselbacher
Deragements of Hepatic Metabolism
1667(5)
Daniel K. Podolsky
Kurt J. Isselbacher
Bilirubin Metabolism and Hyperbilirubinemia
1672(5)
Kurt J. Isselbacher
Acute Viral Hepatitis
1677(15)
Jules L. Dienstag
Kurt J. Isselbacher
Toxic and Drug-Induced Hepatitis
1692(4)
Jules L. Dienstag
Kurt J. Isselbacher
Chronic Hepatitis
1696(8)
Jules L. Dienstag
Kurt J. Isselbacher
Cirrhosis and Alcoholic Liver Disease
1704(6)
Daniel K. Podolsky
Kurt J. Isselbacher
Major Complications of Cirrhosis
1710(7)
Daniel K. Podolsky
Kurt J. Isselbacher
Infiltrative and Metabolic Diseases Affecting the Liver
1717(4)
Kurt J. Isselbacher
Daniel K. Podolsky
Liver Transplantation
1721(4)
Jules L. Dienstag
Diseases of the Gallbladder and Bile Ducts
1725(12)
Norton J. Greenberger
Kurt J. Isselbacher
Section 3 Disorders of the Pancreas
Approach to the Patient with Pancreatic Disease
1737(4)
Phillip P. Toskes
Norton J. Greenberger
Acute and Chronic Pancreatitis
1741(12)
Norton J. Greenberger
Phillip P. Toskes
Kurt J. Isselbacher
Part Twelve DISORDERS OF THE IMMUNE SYSTEM, CONNECTIVE TISSUE, AND JOINTS
Section 1 Disorders of the Immune System
Introduction to the Immune System
1753(24)
Barton F. Haynes
Anthony S. Fauci
The Major Histocompatibility Gene Complex
1777(6)
Charles B. Carpenter
Primary Immune Deficiency Diseases
1783(8)
Max D. Cooper
Alexander R. Lawton III
Human Immunodeficiency Virus (HIV) Disease: AIDS and Related Disorders
1791(65)
Anthony S. Fauci
H. Clifford Lane
Amyloidosis
1856(4)
Jean D. Sipe
Alan S. Cohen
Section 2 Disorders of Immune-Mediated Injury
Diseases of Immediate Type Hypersensitivity
1860(9)
K. Frank Austen
Immunologically Mediated Skin Diseases
1869(5)
Kim B. Yancey
Thomas J. Lawley
Systemic Lupus Erythematosus
1874(6)
Bevra Hannahs Hahn
Rheumatoid Arthritis
1880(8)
Peter E. Lipsky
Systemic Sclerosis (Scleroderma)
1888(8)
Bruce C. Gilliland
Dermatomyositis and Polymyositis
1896(5)
Rup Tandan
Sjogren's Syndrome
1901(3)
Haralampos M. Moutsopoulos
Ankylosing Spondylitis, Reactive Arthritis, and Undifferentiated Spondyloarthropathy
1904(6)
Joel D. Taurog
Peter E. Lipsky
Behcet's Syndrome
1910(1)
Haralampos M. Moutsopoulos
The Vasculitis Syndromes
1910(12)
Anthony S. Fauci
Sarcoidosis
1922(6)
Ronald G. Crystal
Section 3 Disorders of the Joints
Approach to Articular and Musculoskeletal Disorders
1928(7)
John J. Cush
Peter E. Lipsky
Osteoarthritis
1935(6)
Kenneth D. Brandt
Arthritis due to Deposition of Calcium Crystals
1941(3)
Antonio J. Reginato
Gary S. Hoffman
Infectious Arthritis
1944(5)
Scott J. Thaler
James H. Maguire
Psoriatic Arthritis and Arthritis Associated with Gastrointestinal Disease
1949(2)
Peter H. Schur
Relapsing Polychondritis and Other Arthritides
1951(14)
Bruce C. Gilliland
Part Thirteen ENDOCRINOLOGY AND METABOLISM
Section 1 Endocrinology
Approach to the Patient with Endocrine and Metabolic Disorders
1965(7)
Jean D. Wilson
Neuroendocrine Regulation and Diseases of the Anterior Pituitary and Hypothalamus
1972(27)
Beverly M. K. Biller
Gilbert H. Daniels
Disorders of Growth
1999(4)
Raymond L. Hintz
Disorders of the Neurohypophysis
2003(9)
Arnold M. Moses
David H. P. Streeten
Diseases of the Thyroid
2012(23)
Leonard Wartofsky
Diseases of the Adrenal Cortex
2035(22)
Gordon H. Williams
Robert G. Dluhy
Pheochromocytoma
2057(3)
Lewis Landsberg
James B. Young
Diabetes Mellitus
2060(21)
Daniel W. Foster
Hypoglycemia
2081(6)
Daniel W. Foster
Arthur H. Rubenstein
Disorders of the Testes
2087(10)
James E. Griffin
Jean D. Wilson
Disorders of the Ovary and Female Reproductive Tract
2097(18)
Bruce R. Carr
Karen D. Bradshaw
Endocrine Disorders of the Breast
2115(4)
Jean D. Wilson
Disorders of Sexual Differentiation
2119(12)
Jean D. Wilson
James E. Griffin
Disorders Affecting Multiple Endorcrine Systems
2131(7)
Steven I. Sherman
Robert F. Gagel
Section 2 Disorders of Intermediary Metabolism
Disorders of Lipoprotein Metabolism
2138(11)
Henry N. Ginsberg
Ira J. Goldberg
Hemochromatosis
2149(3)
Lawrie W. Powell
Kurt J. Isselbacher
The Porphyrias
2152(6)
Robert J. Desnick
Gout and Other Disorders of Purine Metabolism
2158(8)
Robert L. Wortmann
Wilson's Disease
2166(3)
I. Herbert Scheinberg
Lysosomal Storage Diseases
2169(7)
Margaret M. McGovern
Glycogen Storage Diseases
2176(7)
Yuan-Tsong Chen
Inherited Disorders of Connective Tissue
2183(11)
Darwin J. Prockop
Helena Kuivaniemi
Gerard Tromp
Inherited Disorders of Amino Acid Metabolism and Storage
2194(9)
Louis J. Elsas
Nicola Longo
Leon E. Rosenberg
Inherited Defects of Membrane Transport
2203(5)
Louis J. Elsas
Nicola Longo
Leon E. Rosenberg
Galactosemia, Galactokinase Deficiency, and Other Rare Disorders of Carbohydrate Metabolism
2208(1)
Kurt J. Isselbacher
The Lipodystrophies and Other Rare Disorders of Adipose Tissue
2209(5)
Daniel W. Foster
Section 3 Disorders of Bone and Mineral Metabolism
Calcium, Phosphorus, and Bone Metabolism: Calcium-Regulating Hormones
2214(13)
Michael F. Holick
Stephen M. Krane
John T. Potts, Jr.
Diseases of the Parathyroid Gland and Other Hyper-and Hypocalcemic Disorders
2227(20)
John T. Potts, Jr.
Metabolic Bone Disease
2247(12)
Stephen M. Krane
Michael F. Holick
Disorders of Phosphorus Metabolism
2259(4)
James P. Knochel
Disorders of Magnesium Metabolism
2263(3)
James P. Knochel
Paget's Disease of Bone
2266(3)
Stephen M. Krane
Hyperostosis, Fibrous Dysplasia, and Other Dysplasias of Bone and Cartilage
2269(8)
Stephen M. Krane
Alan L. Schiller
COLOR ATLASES
Part Fourteen NEUROLOGIC DISORDERS
Section 1 Diagnosis of Neurologic Disorders
Approach to the Patient with Neurologic Disease
2277(5)
Joseph B. Martin
Stephen L. Hauser
Electrophysiologic Studies of the Central and Peripheral Nervous Systems
2282(5)
Michael J. Aminoff
Neuroimaging in Neurologic Disorders
2287(6)
William P. Dillon
Molecular Diagnosis of Neurologic Disorders
2293(14)
Joseph B. Martin
Frank M. Longo
Section 2 Diseases of the Central Nervous System
Migraine and the Cluster Headache Syndrome
2307(4)
Neil H. Raskin
Seizures and Epilepsy
2311(14)
Daniel H. Lowenstein
Cerebrovascular Diseases
2325(23)
J. Donald Easton
Stephen L. Hauser
Joseph B. Martin
Alzheimer's Disease and Other Primary Dementias
2348(8)
Thomas D. Bird
Parkinson's Disease and Other Extrapyramidal Disorders
2356(7)
Michael J. Aminoff
Ataxic Disorders
2363(5)
Roger N. Rosenberg
The Motor Neuron Diseases
2368(4)
Robert H. Brown, Jr.
Disorders of the Autonomic Nervous System
2372(5)
John W. Engstrom
Joseph B. Martin
Disorders of the Cranial Nerves
2377(4)
Joseph B. Martin
M. Flint Beal
Diseases of the Spinal Cord
2381(9)
Stephen L. Hauser
Traumatic Injuries of the Head and Spine
2390(8)
Allan H. Ropper
Tumors of the Nervous System
2398(11)
Stephen M. Sagar
Mark A. Israel
Multiple Sclerosis and Other Demyelinating Diseases
2409(10)
Stephen L. Hauser
Donald E. Goodkin
Bacterial Meningitis, Brain Abscess, and Other Suppurative Intracranial Infections
2419(15)
W. Michael Scheld
Chronic and Recurrent Meningitis
2434(5)
Walter J. Koroshetz
Morton N. Swartz
Aseptic Meningitis, Viral Encephalitis, and Prion Diseases
2439(12)
Kenneth L. Tyler
Nutritional and Metabolic Diseases of the Nervous System
2451(6)
M. Flint Beal
Joseph B. Martin
Section 3 Disorders of Nerve and Muscle
Diseases of the Peripheral Nervous System
2457(12)
Arthur K. Asbury
Myasthenia Gravis and Other Diseases of the Neuromuscular Junction
2469(4)
Daniel B. Drachman
Diseases of Muscle
2473(10)
Jerry R. Mendell
Robert C. Griggs
Louis J. Ptacek
Section 4 Chronic Fatigue Syndrome
Chronic Fatigue Syndrome
2483(2)
Stephen E. Straus
Section 5 Psychiatric Disorders
Mental Disorders
2485(18)
Victor I. Reus
Section 6 Alcoholism and Drug Dependency
Alcohol and Alcoholism
2503(5)
Marc A. Schuckit
Opioid Drug Abuse and Dependence
2508(4)
Marc A. Schuckit
David S. Segal
Cocaine and Other Commonly Abused Drugs
2512(4)
Jack H. Mendelson
Nancy K. Mello
Nicotine Addiction
2516(5)
John H. Holbrook
Part Fifteen ENVIRONMENTAL AND OCCUPATIONAL HAZARDS
Specific Environmental and Occupational Hazards
2521(2)
Howard Hu
Frank E. Speizer
Section 1 Illnesses Due to Poisons, Drug Overdosage, and Envenomation
Poisoning and Drug Overdosage
2523(21)
Christopher H. Linden
Frederick H. Lovejoy, Jr.
Disorders Caused by Reptile Bites and Marine Animal Envenomations
2544(4)
Robert L. Norris
Scott Oslund
Paul S. Auerbach
Ectoparasite Infestations and Arthropod Bites and Stings
2548(7)
James H. Maguire
Andrew Spielman
Section 2 Specific Environmental and Occupational Hazards
Drowning and Near-Drowning
2555(2)
Jerome H. Modell
Electrical Injuries
2557(2)
Alan R. Dimick
Radiation Injury
2559(5)
L. Chinsoo Cho
Eli Glatstein
Heavy Metal Poisoning
2564
Howard Hu
APPENDICES
Appendix A: Laboratory Values of Clinical Importance
A-1
Appendix B: Instructions for Collection and Transport of Specimens for Culture
A-9
IndexI-1

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