9783527317660

Adopting a unique approach, this novel textbook integrates science and business for an inside view on the biotech industry. Peering behind the scenes, it provides a thorough analysis of the foundations of the present day industry for students and professionals alike: its history, its tools and processes, its markets and products. The author, himself a close witness of the emergence of modern biotechnology from its very beginnings in the 1980s, clearly separates facts from fiction, looking behind the exaggerated claims made by start-up companies trying to attract investors. He includes a case study of a paradigmatic industry/academic joint venture, while the appendix even features interviews with opinion leaders from the biotech industry conducted specifically for this book. Essential reading for every student and junior researcher looking for a career in the biotech sector.

Born in 1941, Klaus Buchholz studied chemistry at the universities of Saarbr?cken und Heidelberg (Germany), graduating in 1967. In 1969 he received his PhD from the Technical University of Munich, after which he worked as a researcher with a group on biocatalysis at Dechema e.V. in Frankfurt/Main. In 1981 he received his Habilitation at the Technical University of Braunschweig, where he then became department head at the Institute for Agricultural Technology and Sugar Industry. In 1991 he became Professor at the Institute for Chemical Engineering. His main research areas include biocatalysts, enzymatic synthesis of carbohydrates, and environmental biotechnology. He is also the author of a
well-known textbook on biocatalysts and an advisory board member of several journals.

Born in 1945, John Collins studied Microbiology (B.Sc.) at University College, London University, and a doctorate (Ph.D.; 1971) at the University of Leicester, UK. Postdoctoral work was carried out at UCSD, La Jolla 1971-4 with Don Helinski at the time DNA cloning was developed in collaboration with the Cohen and Boyer labs.
He brought this technology to the University of Copenhagen, developing gene cloning methods to isolate and study bacterial and eukaryotic genes and how they are regulated. In 1975 he joined the German National Center for Biotechnological Research (GBF; now HZI) in Braunschweig initiating some of the first experiments to apply gene technology to biotechnological projects (Penicillin acylase, interferon ?; Cytomegalovirus; mutein design of protease inhibitors). In 1987 he accepted a joint appointment as section Head for Cell Biology and Genetics at the GBF and as Professor at the Technical University of Braunschweig. He has worked as international adviser to a number of governments and institutes and lectures on biotechnology, intellectual property, genetics and evolution. He is an elected EMBO (European Molecular Biology Organisation) member and was a founding member of the Human Genome Organistion (HUGO). In 1997 he founded a Biotech Company which was acquired by a Californian Company in 2002. His current work is directed at the development of Inhibitors
of Hepatitis C virus using combinatorial biology as well as trying to explain the impact of scientific developments to the informed public.

Classical Biotechnology
The early period till 1850
The period from 1850 to 1890
The period from 1890 to 1950
From 1950 onwards
The changing focus in biotechnology in the early 1980s -
The OTA report
The Basics Of New Biotechnology
Recombinant technologies
Molecular biotechnology
Industrial (White) Biotechnology
Raw materials, resources, tools
Biocatalysis
Biorefineries
Biofuels, energy, biogas
Bulk chemicals, products for polymers, pharmaceuticals, food and feed
Biopolymers
Fine chemicals - chiral synthons, enzymes, nutraceuticals
Food processing and products
Environmental processes
Pharmaceutical (Red) Biotechnology
Drug targeting, discovery strategies and development
Rational, or structure based strategies
The case of Epothilone
Pharmaceuticals production
Antibiotics and steroids
Recombinant proteins
Cell systems
Medicinal techniques, diagnostics
Business: companies and economic aspects
Political and ethical aspects
Agricultural (Green) Biotechnology
Political, ethical and biosafety aspects
Consumer acceptance and public perception
Crop protection
Products of primary metabolism: carbohydrates, proteins, lipids, biopolymers
Products of secondary metabolism: pharmaceuticals, vitamins, flavors, fragrances
Resistance to fungi and viruses
Resistance to herbicides and drought
Improvements in plant quality and photosynthesis efficiency
Economic aspects
Table of Contents provided by Publisher. All Rights Reserved.

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Concepts in Biotechnology : History, Science and Business

Concepts in Biotechnology : History, Science and Business

352731766X

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