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Bioinformatics and Functional Genomics

ISBN: 9780470085851 | 0470085851

Edition: 2nd
Format: Paperback
Publisher: Wiley-Blackwell
Pub. Date: 5/4/2009

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Summary Table of Contents

The bestselling introduction to bioinformatics and functional genomics-now in an updated editionWidely received in its previous edition, Bioinformatics and Functional Genomics offers the most broad-based introduction to this explosive new discipline. Now in a thoroughly updated and expanded Second Edition, it continues to be the go-to source for students and professionals involved in biomedical research.This edition provides up-to-the-minute coverage of the fields of bioinformatics and genomics. Features new to this edition include:Several fund... MOREamentally important proteins, such as globins, histones, insulin, and albumins, are included to better show how to apply bioinformatics tools to basic biological questionsA completely updated companion Web site, which will be updated as new information becomes availableDescriptions of genome sequencing projects spanning the tree of lifeA stronger focus on how bioinformatics tools are used to understand human diseaseThe book is complemented by lavish illustrations and more than 500 figures and tables-fifty of which are entirely new to this edition. Each chapter includes a Problem Set, Pitfalls, Boxes explaining key techniques and mathematics/statistics principles, Summary, Recommended Reading, and a list of freely available software. Readers may visit a related Web page for supplemental information at www.wiley.com/go/pevsnerbioinformatics.Bioinformatics and Functional Genomics, Second Edition serves as an excellent single-source textbook for advanced undergraduate and beginning graduate-level courses in the biological sciences and computer sciences. It is also an indispensable resource for biologists in a broad variety of disciplines who use the tools of bioinformatics and genomics to study particular research problems; bioinformaticists and computer scientists who develop computer algorithms and databases; and medical researchers and clinicians who want to understand the genomic basis of viral, bacterial, parasitic, or other diseases.

Eagerly awaited, the second edition of the best-selling Bioinformatics and Functional Genomics has been thoroughly updated and enhanced. The text continues to offer the most broad-based introduction to this explosive new discipline, combining theoretical context with practical applications.Bioinformatics and Functional Genomics is a textbook for undergraduate students, graduate students, and anyone involved in biomedical research. The first third of this book covers bioinformatics, a new field at the interface of the ongoing revolutions in molecular biology and computers. A focus of this new discipline is the use of computer databases and computer algorithms to study proteins and genes, including sequence alignment, database searches, and phylogeny. The middle third of this book focuses on functional genomics including approaches such as gene expression profiling and proteomics that are used to study cellular function. The last third of the book is on genomics which is the study of the collection of DNA that comprises an organism, using the tools of bioinformatics. This portion of the book spans the tree of life from viruses to prokaryotes and eukaryotes, including a description of the human genome in health and disease.Highlight features: Attractive two-color design throughout, with a section of full-color figures Lavishly illustrated, featuring over 500 figures and tables with 50 NEW figures and tables in this edition Highlights how the tools of bioinformatics can be used to further our understanding of basic processes in cell and molecular biology and genomics NEW to the second edition: Several fundamentally important proteins (such as histones, insulin, globins, and albumins) are included to better show how to apply bioinformatics tools to basic biological questions Strong focus on the relevance of bioinformatics tools to the understanding of human disease Each chapter includes a Problem Set, Pitfalls section, Boxes explaining key techniques and math/stats principles, Summary, Recommended Reading, and a list of freely available SoftwarePraise for the first edition:"...ideal both for biologists who want to master the application of bioinformatics to real-world problems and for computer scientists who need to understand the biological questions that motivate algorithms." Quarterly Review of Biology"... an excellent textbook for graduate students and upper level undergraduate students." Annals of Biomedical Engineering"...highly recommended for academic and medical libraries, and for researchers as an introduction and reference..." E-Streams

Preface to the Second Edition
Preface to the First Edition
Foreword
Analyzing Dna, Rna, And Protein Sequences In Databases
Introduction
Access to Sequence Data and Literature Information
Pairwise Sequence Alignment
Basic Local Alignment Search Tool (BLAST
Advanced Database Searching
Multiple Sequence... MORE Alignment
Molecular Phylogeny and Evolution
Genomewide Analysis Of Rna And Protein
Bioinformatic Approaches to Ribonucleic Acid (RNA
Gene Expression: Microarray Data Analysis
Protein Analysis and Proteomics
Protein Structure
Functional Genomics
Genome Analysis
Completed Genomes
Completed Genomes: Viruses
Completed Genomes: Bacteria and Archaea
The Eukaryotic Chromosome
Eukaryotic Genomes: Fungi
Eukaryotic Genomes: From Parasites to Primates
Human Genome
Human Disease
Glossary
Answers to Self-Test Quizzes
Author Index
Subject Index
Table of Contents provided by Publisher. All Rights Reserved.

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