9780071387743

This concise text examines cancer causation and biology as well as the biology underlying cancer treatment. Thoroughly updated and reorganized with five new chapters, the Fourth Edition emphasizes new development in molecular biology, hormone therapy, and the pharmacology of anti-cancer drugs. Features updated coverage of the basic science of radiotherapy and experimental radiation in addition to expansive coverage of new drugs developments.

Ian F. Tannock, MD, PhD
Daniel E. Bergsagel Professor of Medical Oncology
Princess Margaret Hospital
University Health Network
Professor of Medicine and Medical Biophysics
University of Toronto
Senior Scientist, Division of Experimental Therapeutics
Ontario Cancer Institute
Toronto, Ontario, Canada

Richard P. Hill, PhD
Senior Scientist, Division of Experimental Therapeutics
Ontario Cancer Institute
Professor, Departments of Medical Biophysics and Radiation Oncology
University of Toronto

Robert G. Bristow, MD, PhD
Assistant Professor
Departments of Radiation Oncology and Medical Biophysics
University of Toronto
Associate Scientist, Division of Experimental Therapeutics
Ontario Cancer Institute

Lea Harrington, PhD
Senior Scientist, Division of Cellular & Molecular Biology
Ontario Cancer Institute/ Amgen Institute
Assistant Professor, Department of Medical Biophysics
University of Toronto

The authors represent the premier cancer research center in Canada. The contributors are primarily located at the Ontario Cancer institute as well.

Contributors

vii

Preface

xi

Introduction to Cancer Biology

1

(3)

Lea Harrington

Robert G. Bristow

Richard P. Hill

Ian F. Tannock

Cancer Epidemiology

4

(21)

John McLaughlin

Steven Gallinger

Chemical and Radiation Carcinogenesis

25

(24)

Allan B. Okey

Patricia A. Harper

Denis M. Grant

Richard P. Hill

Methods of Molecular Analysis

49

(28)

Suzanne Kamel-Reid

Cheryl H. Arrowsmith

Patricia P. Reis

Jeremy A. Squire

Genomic Stability and DNA Repair

77

(23)

Robert G. Bristow

Lea Harrington

Viruses and Cancer

100

(23)

Christopher D. Richardson

Oncogenes and Tumor Suppressor Genes

123

(19)

Sara Oster

Linda Penn

Vuk Stambolic

Cellular Signaling

142

(25)

Melanie A. McGill

C. Jane McGlade

Cell Proliferation and Tumor Growth

167

(27)

Jeffrey C.H. Donovan

Joyce Slingerland

Ian F. Tannock

Cell Death

194

(11)

Razqallah Hakem

Lea Harrington

Tumor Progression and Metastasis: Cellular, Molecular, and Microenvironmental Factors

205

(26)

Rama Khokha

Evelyn Voura

Richard P. Hill

Angiogenesis

231

(18)

Celina Sturk

Daniel Dumont

Imaging in Oncology

249

(12)

Michael D. Sherar

Molecular and Cellular Basis of Radiotherapy

261

(28)

Robert G. Bristow

Richard P. Hill

The Scientific Basis of Radiotherapy

289

(33)

Richard P. Hill

Robert G. Bristow

Pharmacology of Anticancer Drugs

322

(27)

Lillian L. Siu

Malcolm J. Moore

Cellular and Molecular Basis of Drug Treatment for Cancer

349

(27)

Michael J. Boyer

Ian F. Tannock

Drug Resistance

376

(24)

Susan P.C. Cole

Ian F. Tannock

Hormones and Cancer

400

(31)

Paul Rennie

Jason Read

Leigh Murphy

Cancer and the Immune System

431

(22)

Nancy N. Berg-Brown

Linh T. Nguyen

Pamela S. Ohashi

Biological Therapy of Cancer

453

(32)

Neil L. Berinstein

Guide to Studies of Diagnostic Tests, Prognostic Factors, and Treatments

485

(24)

David C. Hodgson

Ian F. Tannock

Glossary

509

(20)

Index

529

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The Basic Science of Oncology

The Basic Science of Oncology

0071387749

Summary

Author Biography

Table of Contents

Supplemental Materials