Officially endorsed by the IUPACs committee on Medicinal Chemistry and Drug Development, this reference continues the success of the two highly acclaimed volumes by the same editors, adding new chapters on general strategies, eight new analogue classes and seven new case studies. With its wide range across a variety of therapeutic fields and chemical classes, this is of interest to virtually every researcher in drug discovery and pharmaceutical chemistry, and -- together with the previous volumes -- constitutes the first systematic approach to drug analogue development.