For more than four decades, scientists and researchers have relied on this series for the most up-to-date information on chromatographic methods and applications. This volume again compiles the work of expert contributors in order to present timely and cutting-edge reviews on a variety of related topics. Each author's clear presentation of topics and vivid illustrations make the material accessible to those at all levels of experience. This edition covers method harmonization, strategies for rapid HPLC development, multidimensional ion chromatography, quantitative in silico analysis, mechanistic aspects of chiral discrimination on protein phases, novel materials for chromatographic analysis, and advances in CE-MS based glycoanalysis.