Advanced Instrumentation & Computer I/O Design, 2nd Edition, employs comprehensive electronic device and circuit specifications to design custom defined-accuracy sensor instrumentation and computer interfacing systems with definitive accountability to assist critical applications. These real-world electrical engineering designs are required by broad users from industrial enterprises to basic research institutions and government laboratories. The initial six chapters develop sensor-amplifier-filter signal conditioning design methods, enabled by device and system mathematical models, to achieve conditioned signal accuracies of interest and follow-on computer data conversion and reconstruction functions. Chapter 7 integrates the preceding chapters to provide complete automated system design analyses employing the Analysis Suite computer-assisted engineering spreadsheet. Chapters 8 and 9 then develop an extension of these performance accountability methods coordinated with versatile and evolving hierarchical subprocess and control architectures, to overcome difficult contemporary process automation challenges combining both quantitative and qualitative methods. Chapter 10 concludes this book with a taxonomy of computer interfaces and standards including telemetry, virtual, and analytical instrumentation. End-of-chapter problems provide enhanced educational value.